Below you will find answers to Frequently Asked Questions (FAQs) about the use of our adhesion barrier products in surgery. This information is designed for use by a medical professional. Please contact us if you have questions that are not presented here.


What is FzioMed’s biomaterial technology?

Read about FzioMed’s patented polymer science in our core science section.

Spine Surgery

What is the difference between Oxiplex®, Oxiplex®/SP, Interpose® and MediShield™ adhesion barrier gels for spine surgery?

No difference. We make our #1 spine anti-adhesion gel available to spine surgeons under 3 brand names. Ask your spine sales representative which brand he/she carries – Oxiplex®, Oxiplex®/SP, Interpose®, or MediShield™ – and rest assured it’s the #1 spine adhesion barrier in the world, made by FzioMed.

How do adhesion barriers work in spine surgery?

Our spine adhesion barrier coats surfaces and creates a temporary physical barrier that protects exposed nerve fibers and dura. It can reduce adhesion formation, so that the nerve is not tethered to spinal structures or compressed by epidural fibrosis. And it may limit exposure of nerves to biochemical irritants that are produced during surgery.

How do I apply the spine adhesion barrier gel?

See Instructions for Use for directions.The spine adhesion barrier gel is supplied sterile, ready-to-use, in a 3mL syringe. Watch the animation video on this site.

Clinical performance of the spine adhesion barrier gel?

Read all about clinical experience and related publications in our reference library.

What are the indications and contraindications for the spine adhesion barrier gel?

For complete prescribing information, see Instructions for Use. FzioMed’s spine adhesion barrier gel (Oxiplex®, Oxiplex®/SP, Interpose® and MediShield™) is indicated for use in posterior lumbar laminectomy, laminotomy or discectomy procedures for reducing pain, radiculopathy, lower extremity weakness, and the incidence, extent and severity of postoperative adhesions.

Nerve/Tendon Surgery

What is Dynavisc?

DYNAVISC is a clear, absorbable gel designed to coat surgically traumatized tissues during tendon and/or peripheral nerve surgeries such as in foot, knee, shoulder, and hand surgery. DYNAVISC acts as a temporary, protective barrier to separate tissues and reduce fibrosis and the formation of post-surgical adhesions.

How does Dynavisc work?

DYNAVISC is designed to coat surfaces exposed in tendon and peripheral nerve surgery – such as in the hand, foot, shoulder and knee – in order to form a temporary mechanical barrier that separates tissues.

DYNAVISC gel remains at the site of application for a period of time, providing a barrier to adhesion formation during the healing process. DYNAVISC is bioabsorbable.

The presence of a temporary barrier gel such as DYNAVISC has been shown to reduce fibrosis and the formation of adhesions.

Tendon adhesion is a function of both an inflammatory response at the surgical site and the loss of physical separation that is normally present between the tendons and synovial sheath. Adhesions bind tendons and nerves to each other and to surrounding structures, interfering with their normal gliding function. The clinical result of adhesion formation following flexor tendon surgery in the hand is poor digital function and pain. Similarly, tethering of nerves can produce tension, which if severe and prolonged, can lead to ischemia and further nerve injury. Reducing extraneural adhesion formation can improve the outcome of surgery and decrease the risk of post-surgical complication.

Peritoneal and Abdominal Surgery

What is Oxiplex/AP?

Oxiplex/AP is intended to be used as an adjunct to intrauterine or peritoneal surgery for reducing the incidence, extent, and severity of postoperative adhesions at the surgical site.

How does Oxiplex/AP work?

Adhesion barriers are a proven method of enhancing good surgical technique by reducing post-surgical adhesions. Oxiplex/AP is designed to coat tissues traumatized during procedures such as:

  • Adhesiolysis
  • Ovarian surgery
  • Tubal surgery
  • Myomectomy
  • Endometriosis
  • Hysterectomy

Application of Oxiplex/AP during surgery is simple and takes only seconds. A single layer of targeted protection of traumatized tissue creates a temporary barrier during healing. Following surgery, the gel is absorbed by the body and does not prevent normal healing.

Last Updated: April 12, 2018