Reference Library

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We welcome you to explore our library of references and publications. If you have questions or need additional information on any of FzioMed's products, please contact us.


Testimonials from users.

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A modern biomaterial for adhesion prevention.

diZerega et al. J Biomed Mater Res B Appl Biomater; Apr 1(1):239-50, 2007.

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Safety of carboxymethylcellulose / polyethylene oxide for the prevention of adhesions in lumbar disc herniation – consecutive case series review.

Fransen et al. Annals of Surgical Innovation and Research; 2(2) 2008.

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New anti-adhesion gel could help make spine revision surgery easier.

Orthopedics Today, March 2006


Application of Oxiplex following spine surgery.



MRI image of Oxiplex at 10 days post-op.



Spine Surgery - Clinical Data

Clinical assessment of a CMC/PEO gel to inhibit postoperative epidural adhesion formation after lumbar discectomy: a randomized, control study.

Liu et al. Arch Orthop Trauma Surg; 133:295-301, 2013


Use of temporary implantable biomaterials to reduce leg pain and back pain in patients with sciatica and lumbar disc herniation.

diZerega et al. Materials; 3:3331-3368, 2010. (Open Access Article)


Oxiplex reduces the incidence of back pain, leg pain and associated symptoms 6 months following single level lumbar laminectomy for removal of herniated disc.

Wang, Arnold & Oxiplex Study Group. Abstract. North American Spine Society (NASS) 2008.


Multicenter study evaluating Oxiplex in lumbar surgery.

Kim, Arnold & Oxiplex Study Group. Abstract. Congress of Neurological Surgeons (CNS) 2008.


Use of Carboxymethylcellulose / Polyethylene Oxide Gel in Microdiscectomy With lnterlaminectomy: A Case Series Comparison With Long-term Follow-up.

Assietti R, Mora A, Brayda-Bruno M. Spine 33(16):1762-1765, 2008.

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Oxiplex reduces the incidence of back pain, leg pain and associated symptoms 6 months following single-level lower lumbar surgery for removal of herniated disc.

Blumenthal S, et al. Poster presentation, Geneva, Switzerland, SpineWeek 2008.


Oxiplex intraoperative gel: an adjuvant to lumbar disc surgery for the reduction of post-surgical pain.

Blumenthal & Oxiplex Study Group. Abstract. Spine Arthroplasty Society(SAS) 2008.


Oxiplex gel reduces neurological sequelae following lumbar surgery.

Arnold & Oxiplex Study Group.  Annual Meeting of the American Association of Neurological Surgeons (AANS), Chicago, 2008.


Use of novel gel-formulated anti-adhesion barrier for prevention of fibrotic adhesions in lumbar micro-discectomy procedures.

Guizzardi R, Morichi R, Vagaggini A, Pandolfo C, Giordano GP. Abstract. Congress of Neurological Surgeons (CNS), October 2006.


Reduction in leg pain and lower extremity weakness with Oxiplex/SP gel for 1 year after laminectomy, laminotomy and discectomy.

Kim et al. Neurosurg Focus 17(1): Clinical Pearl 1, 2004.

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Reduction of radiculopathy and pain with Oxiplex/SP gel after laminectomy, laminotomy, and discectomy: a pilot clinical study.

Kim et al. Spine 15;28(10):1080-7; discussion 1087-8, May 15 2003

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Reduction of Leg Pain by Oxiplex Gel After Lumbar Discectomy in Patients With Predominant Leg Pain and Elevated Levels of Lower Back Pain - A Prospective, Randomized, Blinded, Multicenter Clinical Study

Wei Lei, MD,* Ronald J. Ehmsen, ScD,w Richard P. Chiacchierini, PhD,z
John L. Krelle, MBA,w and Gere S. diZerega, MDy


Supportive Research

The Lumbar Spine Outcomes Questionnaire: its development and psychometric properties.

BenDebba et al. Spine J. 2007 Jan-Feb;7(1):118-32.


Core Science

Evaluation of FzioMed adhesion barrier gel on dural healing in a model of epidural fibrosis in rabbits.

Rodgers KE, et al. Poster. Congress of Neurological Surgeons (CNS), Denver, CO USA, 2003.


Reduction of epidural fibrosis in lumbar surgery with Oxiplex adhesion barriers of carboxymethylcellulose and polyethylene oxide.

Rodgers KE, et al. Spine J, 3:277-284, 2003.

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Hand Surgery - Clinical Data

Prevention of Peritendinous Adhesions after Tenolysis by means of a CarboxyMethylcellulose (CMC), Poly-Ethylene Oxide (PEO) Based Gel: A Light and Electron Microscope Study in the Rabbit

Riccio M. To be published in Hand Surgery


Preliminary report on a new adhesion gel barrier (Dynavisc®) in Hand Surgery.

Di Giuseppe P. Presented at FESSH; Antwerp 2012 & Antalya 2013


The use of Dynavisc(R) in Shoulder Surgery to prevent shoulder stiffness.

Magobotha S. Scheduled for the FzioMed Satallite Symposium at FESSH 2015.


Dynavisc Anti Adhesion Gel in Neurolysis

Battiston B. Presented at FESSH 2014 Paris.

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Last updated: 5 May 2015

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