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Introducing DYNAVISC® gel for adhesion prevention after tendon and peripheral nerve surgery.1

DYNAVISC syringe

DYNAVISC is a clear, absorbable adhesion barrier gel for use in tendon and/or peripheral nerve surgeries such as foot, knee, shoulder, and hand surgery. DYNAVISC acts as a temporary, protective barrier to effectively separate tissues and reduce fibrosis, without interfering with normal healing.2,3,4,5,6,7,8


DYNAVISC is designed to coat surfaces exposed in tendon and peripheral nerve surgery – such as in the hand, foot, shoulder and knee – in order to form a temporary mechanical barrier that separates tissues.

DYNAVISC gel remains at the site of application for a period of time, providing a barrier to adhesion formation during the healing process. DYNAVISC is bioabsorbable.

The presence of a temporary barrier gel such as DYNAVISC has been shown to reduce fibrosis and the formation of adhesions.

Tendon adhesion is a function of both an inflammatory response at the surgical site and the loss of physical separation that is normally present between the tendons and synovial sheath. Adhesions bind tendons and nerves to each other and to surrounding structures, interfering with their normal gliding function. The clinical result of adhesion formation following flexor tendon surgery in the hand is poor digital function and pain. Similarly, tethering of nerves can produce tension, which if severe and prolonged, can lead to ischemia and further nerve injury. Reducing extraneural adhesion formation can improve the outcome of surgery and decrease the risk of post-surgical complication.

A Better Biomaterial for Tendon & Peripheral Nerve Surgery

An effective adhesion barrier gel mechanically reduces the formation of the fibrin scaffolding between healing tissues where adhesion formation can occur. The ability of a gel to coat and separate tissues is related to the rheological properties of viscosity, elasticity, and pseudoplasticity. In addition, the gel must be well tolerated and must not interfere with normal healing.

DYNAVISC gel is formulated from FzioMed's world-leading CMC/PEO biomaterial technology. Studies have shown that coating tissues with CMC/PEO gels can safely prevent formation of adhesions without interrupting normal healing.

DYNAVISC is smooth and colorless, allowing clear view of tendon and neural structures during placement. The flowable, tissue adherent properties of DYNAVISC gel allow thorough tissue coverage. DYNAVISC is backed by the exceptional safety history of FzioMed's biomaterial gel technology.

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Last updated: 19 Aug 2016

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1 DYNAVISC® is currently only available in the European Union. FzioMed's products are not currently available for distribution in the United States.

2 Safety and effectiveness of FzioMed, Inc. gels includes experience in spinal surgery (over 400,000 patients treated), and independent clinical and pre-clinical studies.

3 Fransen P. Safety of carboxymethylcellulose/polyethylene oxide for the prevention of adhesions in lumbar disc herniation – consecutive case series review. Ann Sur Innov Res, 2:2, 2008.

4 Assietti R, et al. Use of carboxymethylcellulose/polyethylene oxide gel in microdiscectomy with interlaminectomy: A case series comparison with long-term follow-up. Spine, 33 (16): 1762-1765, 2008.

5 Arnold P, et al. Oxiplex gel reduces neurological sequelae following lumbar surgery. AANS 2008. Guizzardi G, et al. Use of a novel gel formulated anti-adhesion barrier for prevention of fibrotic adhesions, in lumbar micro-discectomy procedures. Congress of Neurological Surgeons (CNS) 2006.

6 Rodgers, KE, et al. Reduction of epidural fibrosis in lumbar surgery with Oxiplex adhesion barriers of carboxymethylcellulose and polyethylene oxide. Spine J, 3:277-284, 2003.

7 Rodgers KE, et al. Evaluation of FzioMed adhesion barrier gel on dural healing in a model of epidural fibrosis in rabbits. Congress of Neurological Surgeons (CNS) 2003.

8 Data on file, FzioMed, Inc.