Amniotic Membrane

Print This Page Bookmark this Page Email this Page

Aril™ is a natural biologic barrier that provides the protective function of amniotic membrane.1 Amniotic tissue has been shown to reduce the formation of scar tissue, reduce inflammation and accelerate healing.2–7

Aril&trade Amniotic Membrane

Aril™ is produced by utilizing a proprietary decellularization process that has shown a greater than 95% reduction in DNA.

The process has also been shown to preserve the native extracellular matrix and non-cellular constituents such as the basement membrane, fibrous proteins, and non-fibrous proteins, glycosaminoglycans and proteoglycans.8–9

Amniotic Membrane FAQs

What is Amniotic Membrane?

The amniotic membrane is the innermost layer of the placenta which lines the amniotic cavity. The membrane itself is made up of layers of tissue containing specialized cells.

Is there a specific side that must be placed down for the product to work properly?

No. Aril™ is a single layer of amnion which allows the surgeon to place the graft with either side up.

Can the tissue be cut?

Yes, the tissue can be cut to shape based on the surgeon's needs. However, the elliptical shapes of the Aril™ product are designed to maximize the clinical usable surface area and limit preoperative manipulation.

Does the tissue need to be rehydrated before use?

No, the tissue will rehydrate once it is laid in place.

What types of surgery are utilizing amniotic membrane?

Amniotic membranes are being used in spine surgeries such as laminectomies, laminotomies, discectomies, and fusion procedures. In addition, it is being utilized in tendon repair, shoulder repair, various orthopedic procedures and wound repair.

Why would surgeons use amniotic membrane?

Amniotic membrane is a natural biologic barrier that is used to cover and protect adjacent tissues, muscles, nerves, tendons and organs during the critical phase of the healing process. Amniotic membrane has been shown to reduce the formation of scar tissue, reduce inflammation and accelerate healing.

Contact us for availability in your area.

Last updated: 19 Aug 2016

Back to Top

1 Aril™ Acellular Allograft Amniotic Membrane is available in the United States.

2 Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Solomon A et al. Br J Ophthalmol. 2001 Apr;85(4):444-9.

3 Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea. Hao Y et al. 2000 May;19(3):348-52.

4 Expression of natural antimicrobials by human placenta and fetal membranes. Placenta. King AE et al. 2007 Feb-Mar;28(2-3):161-9. Epub 2006 Feb 28.

5 Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions. Tao H, Fan H. Eur Spine J. 2009 Aug;18(8):1202-12. doi: 10.1007/s00586-009-1013-x. Epub 2009 Apr 30.

6 Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Kim JS et al. Exp Eye Res. 2000 Mar;70(3):329-37.

7 Use of dehydrated human amniotic membrane allografts to promote healing in patients with refractory non healing wounds. Sheikh ES et al. Int Wound J. 2013 Feb 15. doi: 10.1111/iwj.12035.

8 Data on file at Seed Biotech, Inc.

9 Early, Ryanne. Decellularized biomaterial form non-mammalian tissue. WO 2014110269, Jul 17, 2014 A1.

Additional References

10. Decellularized biomaterial form non-mammalian tissue. Early, Ryanne. WO 2014110269, Jul 17, 2014 A1.

11. Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. Brown BN et al. Biomaterials. 2009 Mar;30(8):1482-91.

12. Keane TJ, Londono R, Turner NJ, Badylak SF. Consequences of ineffective decellularization of biologic scaffolds on the host response. Biomaterials. 2012 Feb;33(6): 1771-81.

13. Vandevord P, Singla A, Krishnamurthy B. The effects of DNA Extracts from Urological Tissue Matrices. Society for Biomaterials. 2006.